To reduce your possible losses in the event that an opponent goes out, it might be prudent to discard a high-value card that does not contribute to any melds if you have a slots real cashrun of three cards. Think about the value of flexibility as well; it can provide you a big advantage to be able to change your plan of action in response to the game's changing conditions. Early meld formation combined with good hand management and flexibility will help you build a strong strategy that will increase your chances of winning.
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